ErbB signaling pathway
| PAG Title | ErbB signaling pathway |
| PAG ID | WAG001226 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | The ErbB family of receptor tyrosine kises (RTKs) couples binding of extracellular growth factor ligands to intracellular sigling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kise domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Sigling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various sigling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kise (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kise (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kise Src, or the Cbl E3 ubiquitin protein ligase. |
| Species | Homo sapiens |
| nCoCo Score | 4,583 |
| Base PAG ID | WAG001226 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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